Journal Publication – Nalburiye Dergisi http://nalburiyedergisi.com/ Tue, 11 Jan 2022 00:14:58 +0000 en-US hourly 1 https://wordpress.org/?v=5.8 https://nalburiyedergisi.com/wp-content/uploads/2021/07/icon-1.png Journal Publication – Nalburiye Dergisi http://nalburiyedergisi.com/ 32 32 NEJM Evidence – A new journal in the NEJM group family https://nalburiyedergisi.com/nejm-evidence-a-new-journal-in-the-nejm-group-family/ Mon, 10 Jan 2022 22:01:50 +0000 https://nalburiyedergisi.com/nejm-evidence-a-new-journal-in-the-nejm-group-family/ Over the past 20 years, the team at New England Journal of Medicine has reviewed many leading or clinically important research manuscripts that we have not published. Some of the groundbreaking work just wasn’t ready for prime time: studies that revealed new biological knowledge that could one day change practice, but lacked sufficient results to […]]]>

Over the past 20 years, the team at New England Journal of Medicine has reviewed many leading or clinically important research manuscripts that we have not published. Some of the groundbreaking work just wasn’t ready for prime time: studies that revealed new biological knowledge that could one day change practice, but lacked sufficient results to support immediate clinical utility. Many clinically important research trials have posed the reverse problem: Previous work had already established a new paradigm, so even rigorous trials that expand the range of utility of this paradigm have not been found to be new enough. to deserve a publication. This approach made sense and kept the amount of material published in the weekly Newspaper handy. It had one drawback: the Newspaper has not published any transformational work, such as the use of fetal DNA circulating in the blood of a pregnant person to diagnose fetal abnormalities or the use of gamma interferon release tests for the diagnosis of tuberculosis. It also meant that the Newspaper has not published the additional clinical trials that cemented the use of agents active on the PD-L1 pathway in certain cancers where its use has since become the standard of care.

This is about to change. In January 2022, the NEJM Group will start publishing a new journal, Proof of NEJM. This monthly, peer-reviewed, online-only general medical journal will publish original research that takes ideas and turns them into reality. This research includes work across the spectrum of clinical investigation, from the first human demonstrations of safety and potential efficacy that will pave the way for larger and longer clinical trials, at one extreme, to investigations. that strengthen the evidence and push one diagnosis or therapy into widespread use over another.

Corn Proof of NEJM will go even further. The editors of Proof of NEJM believe that understanding the nuances of study design and execution is essential to understanding how the results of a study can, or cannot, influence our clinical practice. Too often readers’ eyes turn glassy when they access the Methods section of a research article; Twenty years ago, when one of us took over as editor-in-chief of Newspaper, the Methods section was even printed in a smaller font than the rest of the article. Understanding the methods of a trial, grappling with the choices investigators were faced with when planning the trial, and assessing the potential impact of the inevitable trade-offs inherent in complex clinical research are essential to understanding how the data ‘a research report can inform your patient’s care in your community.

To meet this challenge head on, Proof of NEJM will provide new direction to make test methods and design attractive. We will post focused commentary on how a trial’s methodology may influence the significance of the observed results to clinical practice. We will present case studies written by investigators who share in depth the challenges they faced and the choices they made during a specific essay (see our first, titled ‘Behind the Scenes of TOPCAT – Taking a Look to inform “). We will develop short educational videos (which we call “Stats, STAT!”) Focusing on high performance statistical methodology relevant to clinicians and researchers. We will provide a platform for clinical trial participants to share their experience, as we work to intentionally raise new and diverse voices and perspectives too often excluded from conversations in academic publishing.

Much of our content will be aimed specifically at clinicians. In addition to the classic journal articles, we will be publishing a number of new types of articles. Our Morning Report series will feature short case reports similar to those experienced by trainees and will be written by members of clinical training programs around the world. The series is designed to bring an evidence-based approach to clinical reasoning. “The Trial of Tomorrow” will invite clinicians to share examples of common medical practice that are not supported by strong evidence and are ripe for a challenge in the form of a randomized trial. We hope this series will shed light on these open clinical questions, advance the discussion of barriers to a definitive answer, and ultimately spawn research to fill in the gaps. Our “Curbside Consult” series will address the clinical dilemmas that physicians face on their daily visits. These short review articles are intended to provide the best current answers to focused questions – short enough to be read quickly and reliable enough to leave the reader comfortable making clinical decisions based on the available evidence.

Proof of NEJM is committed to advancing equity and inclusion in medicine. Our editors, editorial board, statistical reviewers and editors (https://evidence.nejm.org/about/editors-and-publishers) are committed to the principle that patients are best served by work emanating from clinical trials that reflect the patients for whom the diagnoses and therapies under study are to be used. To this end, Proof of NEJM will follow the standard established by the Newspaper in that we will be asking the authors of all original research articles first published in January 2022 or later to provide information explicitly describing the diversity of patients recruited and how this compares to target populations affected by the disease in l ‘study. We are engaged in the active work required to dismantle the structures responsible for the pervasive inequalities that we all face.

In the months and years to come, we will try new approaches and adopt the most effective as we seek to publish the work and commentary that shapes clinical care today and influences research in the next generation. We invite you to join us on this journey by submitting your work to us (https://mc05.manuscriptcentral.com/evidence) as we strive to advance the NEJM Group’s mission: to serve healthcare professionals around the world, so that we can all do a better job of serving patients.

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The body of a missing Illinois boy was found in Indiana; 3 in custody https://nalburiyedergisi.com/the-body-of-a-missing-illinois-boy-was-found-in-indiana-3-in-custody/ Sat, 08 Jan 2022 18:51:09 +0000 https://nalburiyedergisi.com/the-body-of-a-missing-illinois-boy-was-found-in-indiana-3-in-custody/ Update: The mother of a boy who went missing from Illinois was charged with murder on Saturday after the body of the 6-year-old was discovered near an abandoned house in northwest Indiana, the officials said. authorities. Damari Perry of North Chicago was reported missing on Wednesday. His body was found in Gary. Police first learned […]]]>


Update: The mother of a boy who went missing from Illinois was charged with murder on Saturday after the body of the 6-year-old was discovered near an abandoned house in northwest Indiana, the officials said. authorities.

Damari Perry of North Chicago was reported missing on Wednesday. His body was found in Gary.

Police first learned the boy was missing from Skokie, another Chicago suburb, but the investigation turned to Damari’s home “after the family history was contradicted,” said the Lake County State Attorney.

“Our hearts are tight against the murder of 6-year-old Damari Perry.… Prosecutors, investigators and victim support professionals worked late into the night and early in the morning to make sure we understand this tragic crime now, “Eric Rinehart mentioned.

Jannie Perry, 38, has been charged with first degree murder and other crimes. Two other family members also face charges.

It was not immediately clear if Perry had an attorney who could comment on the allegations. She was due in court on Sunday.



NORTH CHICAGO, Ill. (AP) – The body of a missing Illinois boy was discovered in northwest Indiana on Saturday, police said.

Damari Perry’s body was found near an abandoned house in Gary, police said.

The 6-year-old from north Chicago was reported missing on Wednesday.

“Three adult family members suspected of being responsible for Damari’s death are in police custody. … There is no threat to the general public, ”North Chicago Police said.

An autopsy was scheduled.

Damari was last seen Tuesday as he may have traveled to another Chicago suburb, Skokie, with family members, police said.



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Philogen Announces Publication of Clinical Data on PET with Proprietary Small Molecule Ligand Targeting Ultra-High Affinity FAP (OncoFAP) https://nalburiyedergisi.com/philogen-announces-publication-of-clinical-data-on-pet-with-proprietary-small-molecule-ligand-targeting-ultra-high-affinity-fap-oncofap/ Fri, 07 Jan 2022 07:03:51 +0000 https://nalburiyedergisi.com/philogen-announces-publication-of-clinical-data-on-pet-with-proprietary-small-molecule-ligand-targeting-ultra-high-affinity-fap-oncofap/ Philogen announcement publication of Clinical PET The data with an exclusive ultra-high affinity Small molecule ligand targeting FAP (OncoFAP) Translation studies carried out at European Institute of Molecular Imaging and the nuclear medicine department (University and university hospital from Munster) Pin up fast and selective OncoFAP tumor uptake with unprecedented selectivity against healthy organs in […]]]>

Philogen announcement publication of Clinical PET The data with an exclusive ultra-high affinity Small molecule ligand targeting FAP (OncoFAP)

Translation studies carried out at European Institute of Molecular Imaging and the nuclear medicine department (University and university hospital from Munster) Pin up fast and selective OncoFAP tumor uptake with unprecedented selectivity against healthy organs in cancer patients

Philogen, in collaboration with Senn Chemicals, has already produced the equivalent of 1 million BPF doses of clinical grade OncoFAP-DOTAGA

His, Italy, January sevene, 2022 – Philogen SpA, a clinical-stage biotechnology company focused on targeted antibody and small molecule therapies, announces that its 100% Swiss subsidiary, Philochem AG, has co-authored a new translational study on 68Ga-OncoFAP, the best small molecule targeting FAP for applications in cancer and inflammation.

The article, titled “Translational Imaging of Fibroblast Activating Protein (FAP) Using the New Ligand”[68Ga]Ga-OncoFAP-DOTAGA “, has been published in the peer-reviewed journal European Journal of Nuclear Medicine and Molecular Imaging and reports new preclinical and clinical results obtained with 68Ga-OncoFAP.

The data confirmed the rapid and selective accumulation of 68Ga-OncoFAP in solid tumor lesions in disease models and in patient cases. In addition, 68Ga-OncoFAP has shown excellent selectivity against healthy organs, including kidneys, at early times (i.e. disseminated disease).

Dario Neri, Managing Director of Philogen commented : “We are delighted with the translational results presented in our recent article, which demonstrated the strong selectivity of OncoFAP towards healthy organs in cancer patients. In order to pave the way for wider adoption of this technology, we have established a network of nuclear medicine centers on various continents to support our future clinical studies. The equivalent of 1,000,000 GMP-grade doses of OncoFAP-DOTAGA has already been produced in collaboration with Senn Chemicals.

The results presented in this article are the result of a collaboration between the European Institute for Molecular Imaging and the nuclear medicine department at the University and University Hospital Münster and scientists from Philochem AG.

OncoFAP was made under GMP conditions at Senn Chemicals AG, a CDMO in peptide and small molecule synthesis with expertise in small scale GMP production.

Fibroblast activating protein (FAP) has recently emerged as a tumor associated antigen with abundant and selective expression in the majority of human solid malignancies. The discovery of OncoFAP, as well as its preclinical characterization, has recently been reported in Proc Natl Acad Sci United States in April 2021.

Philochem’s OncoFAP derivatives are the small organic ligands with the highest affinity for the FAP antigen reported to date.

OncoFAP is currently under investigation as a modular component for the generation of therapeutics allowing the targeted delivery of a potent beta emitter (lutetium-177), fluorescein-specific CAR T cells and highly auristatin derivatives. cytotoxic.

The article is accessible from European Journal of Nuclear Medicine and Molecular Imaging website under the following IInk.

About Philogen

Philogen is an Italian-Swiss clinical-stage biotechnology company listed on the Italian Stock Exchange. It is engaged in the discovery and development of new pharmaceutical and biopharmaceutical products. Philogen’s strategy is to deliver bioactive agents, eg cytokines or drugs, to the disease site using antibodies and other ligands that specifically and effectively target stromal antigens. This technology has generated a strong proprietary pipeline of clinical stage products and preclinical compounds across a range of disease indications. Philogen is headquartered in Siena, Italy, and carries out research activities at its subsidiary Philochem near Zurich, Switzerland. Philogen has signed agreements with several large pharmaceutical companies. For more information, please visit www.philogen.com and www.philochem.com.

Philogen contacts

Dr Christian Lizak (Business Development), christian.lizak@philogen.com

Dr Emanuele Puca (Investor Relations), emanuele.puca@philogen.com

+41 (0) 43 544 88 00

Contacts Consilium Strategic Communication

Mary-Jane Elliott, Davide Salvi

Philogen@consilium-comms.com


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Toyota overtakes GM as America’s best-selling automaker https://nalburiyedergisi.com/toyota-overtakes-gm-as-americas-best-selling-automaker/ Tue, 04 Jan 2022 23:50:00 +0000 https://nalburiyedergisi.com/toyota-overtakes-gm-as-americas-best-selling-automaker/ The Japanese automaker, which has struggled for decades to expand its presence in the United States, sold approximately 114,000 vehicles to GM in 2021. Toyota’s total sales in the United States of 2 , 3 million, were up about 10% from 2020, the company said on Tuesday. In contrast, GM reported a nearly 13% drop […]]]>

The Japanese automaker, which has struggled for decades to expand its presence in the United States, sold approximately 114,000 vehicles to GM in 2021. Toyota’s total sales in the United States of 2 , 3 million, were up about 10% from 2020, the company said on Tuesday.

In contrast, GM reported a nearly 13% drop in earnings for a total of 2.2 million vehicles sold in 2021, as the semiconductor shortage had a bigger impact on the company’s manufacturing operations. business and left dealerships with fewer vehicles to sell. GM has been the No. 1 car seller in the United States since 1931, according to trade publication Automotive News.

Toyota profited greatly from its decision to stockpile computer chips, which are used in a range of vehicle electronics. It bet earlier than most other automakers on a recovery in the US auto market and cut parts and production orders less sharply than its competitors, better preparing it for a possible increase in consumer demand.

While Toyota executives say they managed to overcome some of the supply chain constraints of the past year, they don’t see the lead over GM as a permanent change in the industry’s closely watched sales rankings. .

“To be clear, that’s not our goal, and we don’t see it as sustainable,” said Jack Hollis, senior vice president of Toyota operations in North America. He added that the company doesn’t expect to use its dethronement from GM last year in its advertising.

A GM spokesperson declined to comment on the company’s sales rankings. He said GM has prioritized its best-selling products – large pickup trucks and sport utility vehicles – and expects sales growth this year as the chip shortage subsides.

Other foreign automakers and electric car maker Tesla Inc.

TSLA -4.18%

It also increased its sales in the United States in 2021, siphoning off market share in Detroit, according to company reports and analyst forecasts.

Hyundai engine Co.

of South Korea, for the second year in a row, recorded significant market share gains, selling 738,081 vehicles in 2021 and increasing sales by about 19% from the previous year, the company said on Tuesday. Mazda engine Corp.

and Honda engine Co.

also recorded above-average sales last year, according to the company’s results.

Need more power? Fancy automated driving? Automakers like Dodge, Polestar, and Jeep are exploring live updates like these as a way to generate new revenue streams and build brand loyalty. George Downs of the WSJ is investigating whether automakers are good at software development. Photographic illustration: George Downs

Research firm Cox Automotive estimates that Tesla’s sales in the United States jumped 61% from the previous year, achieving the biggest percentage gain among automakers. Tesla does not allocate sales to the United States.

Overall, automakers sold just under 15 million vehicles in the United States last year, according to a forecast from research firm JD Power. That total is believed to be up slightly from 2020, when the onset of the Covid-19 pandemic hurt car sales for part of this year. But that’s a steep drop from the 17 million vehicle mark the industry had eclipsed for five consecutive years previously.

Auto stocks rallied on Tuesday after the latest sales results and news that Ford Motor Co.

plans to double the production of its new all-electric truck, after an increase in reservations.

SHARE YOUR THOUGHTS

Did you buy a new car in 2021 or are you planning to buy one in 2022? Why or why not? Join the conversation below.

Ford‘s

the stock closed almost 12% higher on Tuesday. GM shares rose 7.5%, while Toyota’s U.S. certificates of deposit hit a new record high of $ 199.19, up nearly 7% at Tuesday’s close.

Vehicle sales in the United States hit a breakneck pace last spring as American car buyers surfaced, seeking to spend their savings from the pandemic lockdown on new wheels. But in the summer, the chip shortage that had hampered factory hours around the world resulted in near-bare dealer batches, dragging down sales in the second half of 2021.

Forecasters expect another moderate year of vehicle sales, although the chip shortage is expected to gradually ease in the coming months. Auto executives have said it could take a whole year to significantly replenish dealer inventories, which would likely reduce sales despite what dealers say is strong underlying demand.

Edmunds.com expects US sales to reach 15.2 million vehicles in 2022, up slightly from final numbers expected last year. RBC Capital analysts are more bullish, putting the total at around 15.8 million vehicles, with an increase expected later in the year as supply improves.

GM has been among the hardest hit by the chip shortage and other supply chain issues.


Photo:

Mario Tama / Getty Images

Toyota executives said they expected US auto sales to hit around 16.5 million vehicles this year, driven by historically low interest rates, record market performance and higher savings rates that would help support buyers.

High prices are expected to persist, as the seller’s market created by the inventory crisis continues, analysts said. The average price paid for a new vehicle hit a record $ 45,700 in December, up 20% from a year earlier, JD Power estimates.

Record prices for used vehicles are contributing to strong new car prices, JD Power said, as buyers who trade in their old vehicles have more money to work on. The average trade-in vehicle in December was worth about $ 10,200, down from about $ 4,600 a year earlier, the company said.

“Suppressed consumer demand will keep inventory levels near all-time lows,” which will likely lead to more record-breaking prices this year, said Thomas King, president of data and analytics at JD Power.

The uneven disruption of production schedules has blurred the pecking order among automakers in 2021. While chip shortages and other supply chain issues have affected all automakers, GM and Ford have been among the hardest hit, each having scrapped more than 600,000 vehicles planned in North America, according to research firm AutoForecast Solutions LLC.

Stellantis NV, the global automaker that owns Jeep, Ram and other auto brands sold in the United States, has also been disproportionately affected by the chip crisis. It said total US sales of around 1.78 million for 2021, down 2% from the previous year.

Ford plans to release 2021 sales results on Wednesday.

On Tuesday, the Dearborn, Mich., Automaker said it plans to double its manufacturing target for its new electric version of the F-150 pickup truck to 150,000 per year. Ford said the increased production plans reflect strong demand for the model, with around 200,000 reservations placed to purchase one of the trucks.

Other sales winners included Asian and European brands, as well as Tesla, which said on Sunday that global deliveries jumped 87% in 2021, to 936,000 vehicles. Tesla does not break down the sales figures at the regional level. Cox estimated that its market share in the United States fell from 1.4% to 2.2% last year, roughly the same with Mercedes-Benz.

Randy Parker, head of national sales for Hyundai Motor America, said the automaker has taken several steps to address market challenges, including relying more on online sales operations and encouraging dealers to align sales for vehicles that have not yet reached the lot.

He said he expects Hyundai to continue ramping up efforts through 2022, with the aim of building on its recent market share gains.

“I don’t believe in coincidences,” Mr. Parker said. “I think we have adapted extremely well to the crisis. ”

contributed to this article.

How the global flea shortage is affecting you

Write to Mike Colias at Mike.Colias@wsj.com and Christina Rogers at christina.rogers@wsj.com

Copyright © 2022 Dow Jones & Company, Inc. All rights reserved. 87990cbe856818d5eddac44c7b1cdeb8


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MarketInk: Holiday Bowl Association President Deplores COVID Cancellation https://nalburiyedergisi.com/marketink-holiday-bowl-association-president-deplores-covid-cancellation/ Mon, 03 Jan 2022 06:55:00 +0000 https://nalburiyedergisi.com/marketink-holiday-bowl-association-president-deplores-covid-cancellation/ Bob Bolinger in the traditional Holiday Bowl red sports coat. While there weren’t enough bad things throughout 2021, college football fans were disappointed in the final week of the year when the SDCCU Holiday Bowl was called off after the Bruins’ UCLA have decided not to play the game due to COVID-19 reasons. For advertising […]]]>
Bob Bolinger in the traditional Holiday Bowl red sports coat.

While there weren’t enough bad things throughout 2021, college football fans were disappointed in the final week of the year when the SDCCU Holiday Bowl was called off after the Bruins’ UCLA have decided not to play the game due to COVID-19 reasons.

For advertising and broadcast director Bob Bolinger, who served as president in 2021 of the San Diego Ball Game Association, the nonprofit organization that oversees the football game and parade, Holiday Bowl week lasted “quite a week,” he told The Times of San Diego.

On game day, about five hours before the scheduled 5 p.m. kickoff, UCLA issued a statement saying the team would be “unable to participate in tonight’s game due to COVID-19 protocols.”

“At five minutes after noon on game day, I got a phone call from Mark,” said Bolinger, referring to Mark Neville, CEO of the San Diego Bowl Game Association. “At first I thought Mark was joking because he likes to tell jokes. But, this time it wasn’t a joke.

The Tuesday, December 28 game was to be played in a renovated Petco Park, temporarily converted from baseball to football for this unique event. The North Carolina State Wolfpack was scheduled to play at UCLA.


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Examining the Interaction Between Mental Health, Race, Ethnicity, and Acne https://nalburiyedergisi.com/examining-the-interaction-between-mental-health-race-ethnicity-and-acne/ Thu, 30 Dec 2021 21:25:01 +0000 https://nalburiyedergisi.com/examining-the-interaction-between-mental-health-race-ethnicity-and-acne/ Acne patients who come from different racial and ethnic backgrounds may differ with clinical presentation, according to a letter to the editor of the Journal of the American Academy of Dermatology. This can include complications such as post-inflammatory hyperpigmentation (PIH), hypertrophic scarring, and treatment plans.1 Although the differences have been studied, there is still a […]]]>

Acne patients who come from different racial and ethnic backgrounds may differ with clinical presentation, according to a letter to the editor of the Journal of the American Academy of Dermatology. This can include complications such as post-inflammatory hyperpigmentation (PIH), hypertrophic scarring, and treatment plans.1

Although the differences have been studied, there is still a lot to learn about the impact acne has on the mental health of different races and ethnicities. In response, this survey aimed to assess the different impacts of acne on mental health in patients of different racial and ethnic backgrounds.

Nationally, a cross-sectional trial comparing the mental health outcomes of white patients versus those of skin of color (SOC) using the medical expenditure panel survey from 2004 to 2017 Have been realised. The SOC population for the study was defined as patients who identified as Black, Native American / Alaskan Native, Asians, Native Hawaiian / Pacific Islander, or multi-racial.

Overall, 6,952,001 white patients and 1,585,263 SOC patients with acne who reported mental health problems were included in the study data. For more information on the characteristics of these patients, see the table here.

Researchers found that acne patients of all races and ethnicities appeared to have similar mental health issues. “As several studies have suggested that patients with acne are at increased risk for anxiety and depression, it is important to treat acne in patients of all races and ethnicities adequately to reduce the impact of co-morbidities. mental health, ”the authors wrote.2.3

Although no differences were found between the groups, the researchers note that the disparities in access to acne treatment between these groups should be recognized and doctors should advocate for better access to treatment for acne. acne for all patients.

The authors also noted the limitations of the study on the lack of information regarding the severity of acne or complications that may affect mental health outcomes in these patients from the Medical Expenditure Panel Survey.

This article was originally published by sister publication Dermatology Times.

The references

  1. Kohn AH, Pourali SP, Rajkumar JR, Hekmatjah J, Armstrong AW. Mental health outcomes and their association with race and ethnicity in acne patients: a population-based study. Journal of the American Academy of Dermatology. 2021; 0 (0). doi: 10.1016 / j.jaad.2021.06.866
  2. Acne vulgaris and the risk of depression and anxiety: a meta-analytical review. Journal of the American Academy of Dermatology. 2020; 83 (2): 532-541. doi: 10.1016 / j.jaad.2020.02.040
  3. Rogers AT, Semenov YR, Kwatra SG, Okoye GA. Racial Disparities in Acne Management: Data from the National Ambulatory Medical Care Survey, 2005-2014. Dermatological Treatment Journal. 2018; 29 (3): 287-289. doi: 10.1080 / 09546634.2017.1371836


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Hong Kong Police Raid Pro-Democracy Media, Arrest 6 https://nalburiyedergisi.com/hong-kong-police-raid-pro-democracy-media-arrest-6/ Wed, 29 Dec 2021 05:26:15 +0000 https://nalburiyedergisi.com/hong-kong-police-raid-pro-democracy-media-arrest-6/ HONG KONG (AP) – Hong Kong police raided the office of a pro-democracy online media outlet on Wednesday after arresting six people for conspiring to publish a seditious publication, the latest in cracking down on dissent in the city. Those arrested were affiliated with Stand News, one of the city’s most vocal pro-democracy news outlets […]]]>

HONG KONG (AP) – Hong Kong police raided the office of a pro-democracy online media outlet on Wednesday after arresting six people for conspiring to publish a seditious publication, the latest in cracking down on dissent in the city.

Those arrested were affiliated with Stand News, one of the city’s most vocal pro-democracy news outlets after pro-democracy Apple Daily ceased operations earlier this year.

More than 200 officers were involved in the search, police said. They had a warrant to seize relevant journalistic documents under a national security law enacted last year.


The six men were arrested early Wednesday under a colonial-era crimes ordinance for conspiring to publish a seditious publication, and searches of their residences were underway, police said. Those found guilty could face up to two years in prison and a fine of up to HK $ 5,000 ($ 640).

According to the local South China Morning Post, police arrested a current and former editor of Stand News, as well as four former board members, including singer and activist Denise Ho and former lawmaker Margaret Ng. .

Police did not identify those arrested.

A Facebook post early Wednesday morning on Ho’s account confirmed that she was being arrested. A subsequent message posted on her behalf said she was fine and urged her friends and supporters not to worry about her.

This post attracted nearly 40,000 likes and 2,700 comments, mostly from supporters.

Early Wednesday, Stand News posted a video on Facebook showing police officers at the home of deputy editor Ronson Chan, where they were investigating the alleged crime. Chan, who is also chairman of the Hong Kong Journalists Association (HKJA), was taken for questioning, the organization confirmed in a statement.

Chan, who was later released, told media that police seized his electronics, bank cards and press card.

The arrests come as authorities crack down on dissent in the semi-autonomous Chinese city. Hong Kong police previously raided the offices of the now-defunct Apple Daily newspaper, seizing boxes of equipment and hard drives to aid their investigation and freezing millions of assets, which subsequently forced the newspaper to cease its activities.

Police charged former Apple Daily editor Jimmy Lai with sedition on Tuesday.

Earlier this year, Stand News announced that it would be suspending subscriptions and removing most opinion pieces and columns from its website due to national security law. Six members of the board of directors had also resigned from the company.

The HKJA urged the city government to protect press freedom in accordance with Hong Kong’s mini-constitution, the Basic Law.

The Hong Kong Journalists Association (HKJA) is deeply concerned that the police have repeatedly arrested senior media officials and searched news agency offices containing large amounts of journalistic material in the ‘within a year,’ she said in a statement.

Benedict Rogers, co-founder and CEO of the non-governmental organization Hong Kong Watch, said the arrests were “nothing less than a total assault on press freedom in Hong Kong.”

“When a free press guaranteed by Hong Kong’s basic law is called ‘seditious’, it is a symbol of how quickly this once large and open international city has become little more than a police state,” he said. he declared.

Wednesday’s arrests also followed the removal of sculptures and other artwork from college campuses last week. The works supported democracy and commemorated the victims of the Chinese crackdown on Democratic protesters in Beijing’s Tiananmen Square in 1989.


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Today in Johnson City History: December 27 | Life https://nalburiyedergisi.com/today-in-johnson-city-history-december-27-life/ Mon, 27 Dec 2021 05:00:00 +0000 https://nalburiyedergisi.com/today-in-johnson-city-history-december-27-life/ December 27, 1843: In The Jonesborough Whig and Independent Journal, William Henry Maxwell, a lawyer, advertised in an advertisement that he was in business in Jonesborough. No address was provided, nor the opening hours. Jonesborough was spelled this way in 1843. December 27, 1888: The Herald and Tribune reported: “Four of the county’s oldest ladies […]]]>

December 27, 1843: In The Jonesborough Whig and Independent Journal, William Henry Maxwell, a lawyer, advertised in an advertisement that he was in business in Jonesborough. No address was provided, nor the opening hours.

Jonesborough was spelled this way in 1843.

December 27, 1888: The Herald and Tribune reported: “Four of the county’s oldest ladies dined at MJA February’s over Christmas – Ms. Keen and her three sisters. Their total years increased by 301.

“On foot” is a term that means calculating numbers.

The Herald and Tribune was, and still is, a newspaper published in Jonesboro, which was written in 1888. According to the header, the newspaper served both Jonesboro and Johnson City.

December 27, 1896: One hundred and twenty-five years ago today, the Chattanooga Daily Times reported several topics of interest to the Johnson Citians; the items bore a Johnson City signature. “The Ladies’ Library association will be giving an animation for the benefit of the library next Thursday evening. They will organize a prize competition which will be a novelty in entertainment. “

“PH Ponder, private secretary to Congressman Anderson, is spending the holidays at home.”

Ms. Thad A. Cox, who visited her father, WP Brownlow, in Washington, returned home.

Ms. Crandall has traveled to Knoxville again to consult with her attorneys regarding the release of her husband, JE Crandall, from the government prison in Brooklyn, NY. The President is expected to grant pardon. Crandall.

December 27, 1899: The Herald and Tribune reported: “Miss Bessie and Lyla Lyle, of Johnson City, are visiting their mother, Mrs. JI Hawkins.”

As mentioned elsewhere in this column, the Herald and Tribune was, and still is, a newspaper published in Jonesboro, which was spelled in 1899.

December 27, 1900: Much to the children’s delight, The Comet joked, “Hon. Santa Claus was a distinguished visitor to our city this week.

December 27, 1910: The Bristol News reported on a postal savings bank. With a date from Johnson City, readers learned, “Postmaster JA Vines, who returned from a business trip to Washington on Saturday, is very pleased with the potential results of his visit.”

The article continued to say: “His mission in the capital was to take care of the postal savings bank, which was located here; the installation of a substation in the city’s business center and better urban mail distribution.

The Bristol News is no longer published under this name.

December 27, 1918: Readers of the Johnson City Daily Staff have learned that when it comes to Piney Flats, “the flu is rife in this neighborhood again.”

December 27, 1921: A century ago today, The Journal and Tribune reported news with a date from Johnson City. Francis Henley Gilbreath, son of President Sidney G. Gilbreath of East Tennessee State Normal, who is spending the holidays with his parents, reports flattering success at the opening of the De Beriot Conservatory of Music in Philadelphia, Pa., Where he is in charge of the violin department. Mr. Gilbreath and his associates, EJ Barrington, violin, and Mrs. Harman J. Cunningham, piano teacher and accompanist, opened the conservatory on December 1 and already has more than fifty students. outlook indicates the need to add teaching staff in the coming weeks.

East Tennessee State Normal is now known as East Tennessee State University.

The Journal and Tribune was a newspaper published in Knoxville. It ceased publication in 1924. We do not have access to any newspaper published in Johnson City in 1921.

December 27, 1925: The Nashville Tennessean published a story with a date from Johnson City. “Put on a dress and get off,” was the night police chief’s response to an apparently disguised voice asking “my brother’s missing Ford”, “

The intriguing story continued: “As it turns out, my brother’s ‘vanished’ Ford was lying just then in the police garage, from where it had been escorted by two loyal cops after the “car” was found in the city center with a load of Christmas alcohol on board and no one was around when it was found.

The story went on to say, “However, an hour later a call was received, the voice apparently being that of a man trying to fake a female voice. Hence the officers’ suggestion to “put on a robe and go down to headquarters to identify the car”. So far, it has not happened.

December 27, 1925: On the same day, but appearing in The Sunday Star, and with a date from Johnson City, it was reported: “Skyie Oncks was gunned down here last night by Arthur Roberts, a 15 year old boy, who immediately ran away afterwards he had shot Oncks in the head and was not apprehended. The shooting took place in a building. Witnesses told police the boy and the man had an argument and when Oncks walked up to Roberts, the latter pulled out a gun and fired.

The Sunday Star was a Washington, DC newspaper. The other days of the week he was known as the Washington Star. It is no longer in the state of publication.

December 27, 1927: The Morristown Gazette and Mail ran a gruesome story with a date from Johnson City. “A 25 year old son (…) beat Dave Sams, 69, a mountain farmer, to death in his mountain hut near here and set the house on fire, then lay down to sleep in the same room, the officers believed, having reconstructed the tragedy. “

The story continued to report, “The neighbors… found the house on fire and rushed to the spot. Upon breaking down the door, they found the old man beaten to death, a bloodied hammer and a can of kerosene near his body, while he was on a bed in the same room. The son, George, was apparently asleep.

The Morristown Gazette and Mail was a newspaper from Morristown, Tennessee. It is no longer published. Morristown is located approximately 66 miles from Johnson City.

December 27, 1940: The Johnson City Press reported that several young men from the area had recently enlisted in the service. “… The candidates were accepted for the US Army yesterday by Sergeant Charley R. Price, recruiting officer in charge of the local substation. All were taken for three-year enlistments in the regular army.

The article continued to say that 20-year-old Matt Camack, son of Kenneth W. Carmack from Imboden, Va., Had enlisted. Roy Butler, 22, whose parents were Mr. and Mrs. Mitchell in Buladeen, North Carolina, is reportedly traveling to Fort Benning, Georgia. Roy Butler’s brother Loyd Woodrow Butler, 17, was accepted into the US Navy because he was too young to enlist in the military. Paul Waycaster, 19, son of Mrs Mandy Hill of Roan Mountain and Eugene Sluder, 18, son of Mr and Mrs Galen Sluder, and Lester Lee Stroupe, 19, son of Mrs and Mrs Harry Stroupe of Erwin would all go to Fort Benning.

December 27, 1950: The Elizabethton Star reported news of a chemical process patent. “Dr. Hugo Hofmann, Plant Manager of the US Bemberg Division of Beaunit Mills, Inc., is the assignor of a patent which covers the process of recovering the mixture of copper oxide and tartrate from solutions of wastes occurring in the manufacturer of euperammonium rayon yarn, according to “Official Gazette,” the publication of the United States Patent Office in Washington. “

On the same day, and also according to the Elizabethton Star, “Watauga Lake was reported at an elevation of 1,936.47 feet this morning, making the level 22.53 feet below the full pool and 38, 53 feet below the spillway “.

“Yesterday, the highest temperature reached was 53 and the low last night was 23. A high of 28 is expected today, with a low of 13 forecast for tonight.”

“Good weather is forecast for today, tonight and Thursday, with a high temperature of 36 expected tomorrow.”

The Elizabethton Star is still in publication condition.

December 27, 1952: Miss Jacqueline Joyce Hughel became the wife of Mr. Leonard Lee Runyan.

December 27, 1960: The Johnson City Press-Chronicle reported: “Admitted to Memorial Hospital last Thursday for treatment of burns sustained in an explosion at Main Street Café, Dale Wiseman, Rt. 2, Pinecrest, was released yesterday.

Memorial Hospital was the forerunner of Johnson City Medical Center.

December 27, 1970: Johnson City Press-Chronicle columnist Gerald Squibb wished his readers “Happy New Year from House Squibb.”


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Oak Brook Center shooting incident official update https://nalburiyedergisi.com/oak-brook-center-shooting-incident-official-update/ Fri, 24 Dec 2021 07:52:27 +0000 https://nalburiyedergisi.com/oak-brook-center-shooting-incident-official-update/ Authorities are still looking for an additional suspect. He is described as a black man with long dark dreadlocks who appears to be in his thirties, with an average build and average height. | Photo: Supplied. OAK BROOK, Illinois – Authorities provided us with an official update on their investigation into the shooting Thursday night […]]]>
Authorities are still looking for an additional suspect. He is described as a black man with long dark dreadlocks who appears to be in his thirties, with an average build and average height. | Photo: Supplied.

OAK BROOK, Illinois – Authorities provided us with an official update on their investigation into the shooting Thursday night at one of metro Chicago’s busiest malls on Christmas Eve.

Officials estimate the mall was at over 80 percent of capacity at the time of the shooting.



Police told us that at approximately 5:44 p.m. on the second floor of the Nordstrom Wing near the Ann Taylor in Oakbrook Center Mall, an as yet unconfirmed number of shots were fired, injuring four people.

There were two suspected shooters and one individual listed as a companion who were involved in a confrontation which led to an exchange of gunfire.

“This is just a very unfortunate incident which is completely irrelevant to our region,” said Police Chief James Kruger.

The open-air mall is a major shopping destination about 15 miles west of Chicago. TV channels equipped with aerial cameras showed police cars and emergency vehicles spread across the property with their lights flashing.

An Oak Brook police officer working an additional detail at Nordstrom heard the gunshots and immediately responded to the scene. With the help of mutual aid police units and Oakbrook Center Security, the mall was locked down and two people involved were taken into custody.

One offender was shot four times: once in the left thigh, once in the right thigh, once in the right calf, and once in the lower back. Police immediately provided life-saving first aid to the suspect and the suspect underwent successful surgery and is expected to survive.



Four other injuries were reported.

Witnesses described a woman in her 40s who was shot in the left thigh, another woman in her 40s who was shot in the left thigh and a woman in her 20s who was shot in the right foot. The fifth victim, a woman in her twenties, broke her ankle while fleeing the scene.

The female bullet victims are all recovering at Good Samaritan Hospital in Downers Grove, while the woman with the fractured ankle is at Elmhurst Hospital. All should be non-life threatening injuries.

Oak Brook police officers arrested a suspect as he attempted to leave the area.

Police have a suspected gunman and his companion in custody. There is a suspected gunman still at large. The offender in general is a black male with long dark dreadlocks who appears in his thirties, of average build and height.

Two weapons described as pistols and a vehicle registered in the name of one of the suspects were recovered from the scene.

The police secured the mall at around 11:55 p.m. and handed it over to the mall management.

Buyers interviewed as they were released said they hid in shops and locker rooms.

The investigation and search for the additional suspect is continuing.



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Recently published results showed that spesolimab significantly improved the signs and symptoms of flare-ups in rare and life-threatening skin diseases, generalized pustular psoriasis https://nalburiyedergisi.com/recently-published-results-showed-that-spesolimab-significantly-improved-the-signs-and-symptoms-of-flare-ups-in-rare-and-life-threatening-skin-diseases-generalized-pustular-psoriasis/ Thu, 23 Dec 2021 13:41:12 +0000 https://nalburiyedergisi.com/recently-published-results-showed-that-spesolimab-significantly-improved-the-signs-and-symptoms-of-flare-ups-in-rare-and-life-threatening-skin-diseases-generalized-pustular-psoriasis/ RIDGEFIELD, Connecticut., 23 December 2021 / PRNewswire / – Boehringer Ingelheim today announced the publication in The New England Journal of Medicine new data from the pivotal Phase II Effisayil ™ 1 trial, which showed that spesolimab, a first-class investigational treatment, significantly improved the signs and symptoms of generalized pustular psoriasis (GPP) in patients with […]]]>

RIDGEFIELD, Connecticut., 23 December 2021 / PRNewswire / – Boehringer Ingelheim today announced the publication in The New England Journal of Medicine new data from the pivotal Phase II Effisayil ™ 1 trial, which showed that spesolimab, a first-class investigational treatment, significantly improved the signs and symptoms of generalized pustular psoriasis (GPP) in patients with relapse .

PPG is a rare and life-threatening neutrophilic skin disease distinct from plaque psoriasis. It is characterized by episodes of generalized eruptions of painful and sterile pustules (blisters of non-infectious pus). There is a great unmet need for treatments that can quickly and completely resolve the signs and symptoms of PPM flare-ups. Flare-ups greatly affect a person’s quality of life and can lead to hospitalization with serious complications, including heart failure, kidney failure, sepsis, and death.

In the 12-week trial, 53 patients with a flare-up of GPP were treated with a single intravenous dose of spesolimab or placebo. Most of the patients at the start of the trial had high or very high pustule density and impaired quality of life. The results after one week showed that:

  • 54% of patients treated with spesolimab had no visible pustules, compared to 6% of those treated with placebo
  • 43% of patients treated with spesolimab had fair / almost fair skin, compared to 11% of those in the placebo group

After one week of treatment, spesolimab was associated with a higher number of infections and systemic drug reactions compared to placebo.

In some patients, pustular and dermal clearance were maintained throughout the study. This clearance was accompanied by clinically significant improvements in quality of life and in symptoms such as pain and fatigue. Adverse events were reported in 66% of patients treated with spesolimab and 56% of those receiving placebo after the first week. Infections were reported by 17% and 6% of patients in the spesolimab and placebo groups, respectively. Serious adverse events were reported in 6% of patients treated with spesolimab. Two patients receiving spesolimab experienced drug reactions with eosinophilia and systemic symptoms.

“With the absence of approved treatments in the United States for flare-ups of GPP, there is a significant unmet need for people with this distressing and painful skin condition, which often requires emergency care,” said Marc Lebwohl, MD, Principal Investigator and Publication Author, and Dean of Clinical Therapeutics, Icahn School of Medicine at Mount Sinai, Kimberly and Eric J. Waldman Department of Dermatology, New York. “These clinical trial results show that spesolimab has the potential to clear the skin of signs and symptoms of a GPP flare after just a week, with effects seen until the end of the study.”

The United States Food and Drug Administration (FDA) has accepted a Biologics License Application (BLA) and granted priority review to spesolimab for the treatment of GPP flare-ups. The FDA has granted orphan drug designation to spesolimab for the treatment of GPP and breakthrough therapy designation to spesolimab for the treatment of outbreaks of GPP in adults.

“At Boehringer Ingelheim, we are committed to finding transformative therapies to help advance treatment for those in urgent need,” said Matt frankel, MD, Vice President, Clinical Development and Medical Affairs, Specialty Care, Boehringer Ingelheim. “The results indicate that spesolimab can have a significant and positive impact on the well-being of patients with a flare-up of GPP.”

The spesolimab clinical program includes two other trials currently underway. The Effisayil ™ 2 study will evaluate the safety and efficacy of spesolimab for the treatment of PPM, including prevention of relapses and symptom control over 48 weeks. Effisayil ™ ON is a five-year, open-label extension study that will provide additional long-term efficacy and safety data for spesolimab in the treatment of GPP.

About spesolimab

Spesolimab is a novel humanized selective antibody that blocks activation of the interleukin-36 receptor (IL-36R), a signaling pathway within the immune system involved in the pathogenesis of several autoimmune diseases, including GPP . Spesolimab is also being studied for the prevention of GPP flare-ups and for the treatment of other neutrophilic skin diseases, such as palmoplantar pustulosis (PPP) and hidradenitis suppurativa (HS).

About the Effisayil ™ 1 clinical trial

Effisayil ™ 1 (NCT03782792) was a 12-week phase II trial in patients with an outbreak of GPP (N = 53), randomly assigned 2: 1 to a single 900 mg intravenous dose of spesolimab or placebo. The primary endpoint was a GPP Physician Global Assessment (GPPGA) pustulation sub-score of 0 (no visible pustules) at week 1. The key secondary endpoint was a GPPGA score of 0/1 (light / almost light skin) at week 1.

After one week, 54% of patients (19 of 35) treated with spesolimab had no visible pustules (GPPGA score of 0), compared with 6% of patients (1 of 18) treated with placebo (P <0.001). In addition, 43% of patients (15 out of 35) treated with spesolimab had fair / almost fair skin (GPPGA score of 0/1), compared to 11% of patients (2 of 18) in the placebo group (P = 0.024) .

About generalized pustular psoriasis (PPP)

GPP is a rare, heterogeneous, and life-threatening neutrophilic skin disease that is clinically distinct from plaque psoriasis. GPP is caused by the buildup of neutrophils (a type of white blood cell) in the skin, resulting in painful, sterile pustules all over the body. The clinical course varies, with some patients having recurrent disease with recurrent flares, and others having persistent disease with intermittent flares. Although the severity of GPP flares can vary, if left untreated they can be life threatening due to complications such as sepsis and multiple organ failure. This chronic systemic disease has a substantial impact on the quality of life of patients and the burden of health care. GPP has a varied prevalence in different geographic regions and more women are affected than men.

Boehringer Ingelheim Immunology: pioneering science, inspired by patients

Living with fibrotic and inflammatory diseases has a huge impact on the lives of patients, emotionally and physically. These patients are our guides, partners and inspirers as we redefine treatment paradigms. As a family business, we can plan for the long term. Our goal is to discover and develop unique therapies. With a deep understanding of molecular pathways, we are at the forefront of scientific breakthroughs that target, repair and prevent many fibrotic and inflammatory diseases. By relying on long-term external collaborations, we strive to bring therapeutic breakthroughs to patients as soon as possible. We won’t rest until we can give people a chance to live the life they want.

Boehringer Ingelheim

Boehringer Ingelheim is working on breakthrough therapies that improve the lives of humans and animals. As a leading research-driven biopharmaceutical company, the company creates value through innovation in areas where unmet medical needs are great. Founded in 1885 and family-owned ever since, Boehringer Ingelheim takes a long-term perspective. Approximately 52,000 employees serve more than 130 markets in the three business areas, human pharmacy, animal health and biopharmaceutical contract manufacturing. Learn more about www.boehringer-ingelheim.com.

MPR-US-101856

Media contact

Christophe wahlers
Boehringer Ingelheim Pharmaceuticals, Inc.
Telephone: +1 203.798.4375
Email: christopher.wahlers@boehringer-ingelheim.com

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SOURCE Boehringer Ingelheim Pharmaceuticals


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