Related Maternal Cholesterol During Pregnancy

Sophia Antipolis, October 19, 2021: A small study suggested that high maternal cholesterol levels during pregnancy are associated with more serious heart attacks in young adults. The research is published today in the European Journal of Preventive Cardiology, a journal of the European Society of Cardiology (ESC).1

“Cholesterol is not routinely measured during pregnancy in most countries, so there are few studies on its association with the health of the offspring,” said study author Dr Francesco Cacciatore. from the University of Naples Federico II, Italy.

“More research is needed to verify our results,” he continued. “If confirmed, this association would indicate that high cholesterol levels during pregnancy should be taken as a warning sign and that women should be encouraged to exercise and reduce their cholesterol intake. In addition, affected children could receive diet and lifestyle counseling aimed at preventing heart disease later in life. “

The retrospective study included 310 patients admitted to hospital between 1991 and 2019. Of these, 89 patients were admitted with a heart attack and 221 controls were hospitalized for other reasons. For the 310 participants, data was obtained on the mother’s cholesterol during the first and second trimester of pregnancy with this person.

The average age of the 89 heart attack patients was 47, and 84% were men. Patients were classified as having a severe or non-severe heart attack according to: 1) the number of coronary arteries involved (severe attack = involving three arteries); 2) pumping function of the heart (severe seizure = left ventricular ejection fraction 35% or less); 3) peak levels of creatinine kinase (CK) and CK-MB enzymes, with higher levels indicating more extensive heart damage (severe seizure = CK peak above 1200 mg / dL or CK peak -MB above 200 mg / dL). The heart attack was considered serious when at least one of the criteria was met.

Maternal cholesterol during pregnancy was significantly correlated with each measure of heart attack severity (number of vessels, ejection fraction, CK and CK-MB).

Researchers analyzed the association between maternal cholesterol during pregnancy and the severity of the heart attack after adjusting for age, sex, body mass index (BMI), number of risk factors cardiovascular (obesity, smoking, high blood pressure, family history of heart disease or high cholesterol). , diabetes, previous angina) and serum cholesterol measured after hospitalization for heart attack.

Maternal cholesterol during pregnancy predicted heart attack severity regardless of age, sex, BMI, number of risk factors, and serum cholesterol after hospitalization, with an odds ratio of 1.382 (range of 95% confidence 1.046-1.825; p = 0.023).

In a second analysis including 310 patients, researchers examined the association between maternal cholesterol during pregnancy and atherosclerosis in adult children. As no measure of atherosclerosis was available for most controls, two surrogate measures were used. These were: 1) number of cardiovascular risk factors; and 2) the number of cardiovascular risk factors plus clinical manifestations such as heart attack or stroke.

The cholesterol level of pregnant mothers was significantly correlated with both measures of atherosclerosis risk, even after adjusting for age, sex, and cardiovascular risk factors.

Dr Cacciatore said: “Our observations suggest that a mother’s cholesterol level during pregnancy has an impact on the developmental programming of the offspring and on the severity of heart attack in adulthood. However, the study does not establish a causal link, nor does it allow us to estimate the amount of maternal cholesterol that may contribute to the severity of a heart attack.

He concluded: “Prospective studies are needed to better assess the extent to which maternal cholesterol may influence the development of atherosclerosis in offspring and the combined effect of risk factors throughout life.

ENDS

Authors: CES Press Service
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Funding: Supported by the Italian Ministry of Health Progetto di Ricerca Finalizzata 2007-2009 (FC), the National Institutes of Health subsidize HL067792 and HL089559 (WP and CN), Progetto di Rilevanza Nazionale from the Italian Ministry of University and Research PRIN 2017 (CN) and Ellison Medical Foundation Principal Investigator Fellowship 1851-07 (WP).

Disclosures: None declared.

Remarks

The references

1Cacciatore F, Bruzzese G, Abete P, et al. Maternal hypercholesterolemia during pregnancy affects

severity of myocardial infarction in young adults. Eur J Prev Cardiol. 2021. doi: 10.1093 / eurjpc / zwab152.

The link will be online as soon as it is published:

https://academic.oup.com/eurjpc/article-lookup/doi/10.1093/eurjpc/zwab152

About the European Society of Cardiology

The European Society of Cardiology brings together healthcare professionals from more than 150 countries, working to advance cardiovascular medicine and help people live longer and healthier lives.

About the European Journal of Preventive Cardiology
The European Journal of Preventive Cardiology is the world’s leading journal of preventive cardiology, playing a central role in reducing the global burden of cardiovascular disease.


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